# bio-catalyst

> Agent-payable source-anchored biotech/pharma catalyst calendar — clinical-trial readout windows (ClinicalTrials.gov) and FDA Advisory Committee (AdComm) meetings (Federal Register), each linked to its official source and labelled confirmed vs estimated. Public scheduling data, not investment advice. Built for autonomous AI agents.
> Pay-per-call over the Model Context Protocol using the x402 "Payment Required"
> standard (Coinbase x402, USDC on base). No signup, no API key to read the
> free tiers; pay only for the premium result.

## MCP endpoint

- https://biocatalyst.dropwatchhq.com/mcp  (transport: streamable-http; call tools/list then tools/call)

## Paid tools (x402 pay-per-call, USDC on base)
- `upcoming_catalysts` — $0.02 USDC/call. Full source-anchored upcoming-catalyst set (date, dateType/confirmation, ticker, drug, official source URL, verified-as-of) filtered by horizon/kind/phase.

## Free tools
- `catalyst_for_company` — free. Source-anchored catalysts for a public-company ticker.
- `catalyst_for_drug` — free. Source-anchored catalysts referencing a drug/product.

## How an agent pays (x402 over MCP)

1. POST https://biocatalyst.dropwatchhq.com/mcp with JSON-RPC tools/call for a paid tool. The result returns a
   FREE PREVIEW plus an `x402` descriptor inside structuredContent:
   { "x402Version":1, "accepts":[ { "scheme":"exact", "network":"base",
     "maxAmountRequired":"<atomic USDC>", "asset":"<USDC on Base>",
     "payTo":"0x38134a7F97636E26365Fb17405566595B917a341", "extra":{"name":"USD Coin","version":"2"} } ] }
2. Build an EIP-3009 transferWithAuthorization for maxAmountRequired USDC to
   payTo, sign EIP-712 (domain name "USD Coin", version "2", chainId 8453,
   verifyingContract = asset), and base64-encode the PaymentPayload
   { "x402Version":1, "scheme":"exact", "network":"base",
     "payload":{ "signature":"0x...", "authorization":{ from,to,value,validAfter,validBefore,nonce } } }
3. Retry the SAME tools/call with header  X-PAYMENT: <base64 payload>
   -> the full result, plus an X-PAYMENT-RESPONSE header (settlement receipt).

The x402 client SDKs (x402-fetch / x402-axios) automate steps 1-3.

## Payment facts

- Network: base (Base mainnet). Asset: USDC (6 decimals).
- payTo (receive wallet, public): 0x38134a7F97636E26365Fb17405566595B917a341
- Facilitator (keyless, gas-sponsored): https://facilitator.payai.network

## Spec

Implements x402 v1 (scheme "exact", EVM EIP-3009). See
https://github.com/coinbase/x402 and https://docs.x402.org .
Machine descriptor: https://biocatalyst.dropwatchhq.com/.well-known/x402